Maryam Shokouhi; Behnaz Basiri; Mohammad Kazem Sabzehei; Masoumeh Mahdiankhoo; Azar Pirdehghan
Volume 21, Issue 2 , 2019, Pages 1-7
Abstract
Background: Neonatal respiratory distress syndrome (RDS) is a problem that often occurs in preterm neonates.Objectives: The present study was conducted to compare the efficacy and complications of humidified high flow nasal cannula(HFNC) with those of nasal continuous positive airway pressure (NCPAP) ...
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Background: Neonatal respiratory distress syndrome (RDS) is a problem that often occurs in preterm neonates.Objectives: The present study was conducted to compare the efficacy and complications of humidified high flow nasal cannula(HFNC) with those of nasal continuous positive airway pressure (NCPAP) after surfactant therapy in neonates with RDS.Methods: This clinical trial was conducted on 60 neonates with the gestational age of 28 - 36 weeks suffering from RDS and admittedto Fatemieh Hospital in Hamadan, Iran, during 2017. Initially, all newborns were administered with exogenous surfactant. Subse-quently, the participants were randomly assigned into two groups of HFNC (group 1) and NCPAP (group 2) to receive respiratorysupport. The NCPAP group was managed with a mask or nasal prong. The HFNC group was given warm and humid oxygen througha short binasal cannula proportional to the weight of each neonate until the recovery of respiratory distress.Results: The mean one-minute Apgar scores were obtained as 6.23 ± 1.55 and 6.60 ± 1.07 in the HFNC and NCPAP groups, respec-tively. Furthermore, the mean five-minute Apgar scores were 8.0 ± 1.11 and 8.17 ± 0.95 in these groups, respectively. The mothersand neonates in both groups were comparable in terms of demographic and clinical data, except for gestational age and neonatalgender (P = 0.05). Furthermore, there was no statistically significant difference between the HFNC and NCPAP groups regarding therespiratory outcomes (P = 0.05).Conclusions: As the findings indicated, humidified high flow nasal cannula was as effective as nasal continuous positive airwaypressure in the management of respiratory distress in premature neonates with the gestational age of 28 - 36 weeks. Consequently,these two interventions could be used interchangeably for the provision of respiratory support among these patients.
Mohammad Kazem Sabzehei; Behnaz Basiri; Maryam Shokouhi; Afshin Fayyazi; Fatemeh Eghbalian
Volume 20, s1 , December 2018, , Pages 1-5
Abstract
Background: Transient tachypnea of the newborn (TTN) is one of the important causes of neonatal respiratory distress and hospitalization in the neonatal intensive care unit (NICU). Objectives: The current study aimed at identifying the risk factors of TTN in a single tertiary care center. Methods: The ...
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Background: Transient tachypnea of the newborn (TTN) is one of the important causes of neonatal respiratory distress and hospitalization in the neonatal intensive care unit (NICU). Objectives: The current study aimed at identifying the risk factors of TTN in a single tertiary care center. Methods: The current prospective, case-control study was conducted on 180 newborns allocated in the 2 groups of with TTN (n = 90) as the case group, and without TTN (n = 90) as the control group for 1 year from April to March 2015 in a public hospital of Hamadan, Iran. Newborn and mother’s information was extracted from their medical records. Diagnosis of TTN was based on clinical and radiological findings, after ruling out other respiratory distress causes. Data were analyzed using logistic regression and P < 0.05 was considered the level of significance. Results: The raw data analysis of regression factors associated with TTN showed that the risk of TTN was higher in late preterm infants (odds ratio (OR): 6.15; 95% confi- dence interval (CI): 3.17 - 11.92, P = 0.001) as well as male newborns (OR: 0.33, 95% CI: 0.17 - 0.62, P = 0.001), and those born by cesarean (OR: 11.22, 95% CI: 5.33 - 23.62, P = 0.001). Moreover, the risk of TTN increased with Apgar score in the first minute (OR: 0.02.95% CI: 0.00 - 0.05, P = 0.001) and decreased with the fifth minute (OR: 0.02; 95% CI: 0.00 - 0.06, P = 0.001). The results of multiple regression analysis showed that the odds of TTN of late preterm newborns was 2.96 times higher than that of term newborns(OR: 2.96, 95% CI: 1.09 - 8.04, P = 0.033). Furthermore, with increase in Apgar score in the first minute, the risk of TTN reduced (OR: 0.02; 95% CI: 0.01 - 0.07, P = 0.001). Conclusions: Prematurity and Apgar score in the first minute were the risk factors for TTN. Consequently, the risk of TTN can be reduced by the prevention of preterm birth and improvement of perinatal care.
